TWO NEW FACTORS IN BLOOD COAGULATION—HEPARIN AND PRO-ANTITHROMBIN
نویسندگان
چکیده
منابع مشابه
Two New Factors in Blood Coagulation-heparin and Pro-antithrombin
A survey of the results of recent work indicates that at least six different substances are concerned in one way or another in the process of blood coagulation; namely, fibrinogen, thrombin, prothrombin, calcium, antithrombin and the so-called zymoplastic or thromboplastic substances furnished bv the body cells in general, including the blood corpuscles. With regard to the last mentioned factor...
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New antithrombin-based anticoagulants.
Clinically used anticoagulants are inhibitors of enzymes involved in the coagulation pathway, primarily thrombin and factor Xa. These agents can be either direct or indirect inhibitors of clotting enzymes. Heparin-based anticoagulants are indirect inhibitors that enhance the proteinase inhibitory activity of a natural anticoagulant, antithrombin. Despite its phenomenal success, current anticoag...
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A test is described for the estimation of antithrombin in the blood. The chief advantage of the test is that it is simple, and does not require the preparation of fibrinogen and of thrombin, which are difficult to prepare and to maintain in a pure state. The principle consists in titrating the antithrombin against normal human plasma; in this way we obtain an estimation of its power to delay co...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Legacy Content
سال: 1918
ISSN: 0002-9513
DOI: 10.1152/ajplegacy.1918.47.3.328